What caused Karl to lose it this time?

Today host Karl Stefanovic interviews Grumpy cat. Courtesy Channel Nine/Today

Karl Stefanovic loses it on TV during his interview with Grumpy Cat. Picture: Screengrab Source: Supplied

ONE is a global internet sensation with her own YouTube channel and thousands of memes.

The other is pure web gold.

So what happens when Grumpy Cat and Karl Stefanovic go head to head in an interview?

The Today host ended up in hysterics during his "exclusive" interview with Grumpy Cat.

Admitting it was a challenge interviewing a subject who couldn't speak, Stefanovic asked television viewers to concentrate on the cat's face, and not his questions.

He began by asking the popular feline if Monday was her favourite day of the week, but got no response.

Stefanovic then moved onto her upcoming book, before asking about her views on our politicians.

"What do you think of our politicians," he asked.

"Do you like our Prime Minister Kevin Rudd? What about Opposition Leader Tony Abbott?"

Grump Cat frowned.

But fortunately viewers were spared any more political talk after Stefanovic broke into fits of laughter before saying "Look at the cat, she looks like Jabba the Hutt."

He later told co-host Lisa Wilkinson it was hard to talk to a subject with such a funny face.

The TV host struggles to keep a straight face. Picture: Screengrab Source: Supplied

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